MEDICINE AT THE CRICK - NEW FRONTIERS IN DRUG DISCOVERY

More about the event

This 15th edition of Medicine at the Crick will be hosted as a full day event by Anne Schreiber (The Francis Crick Institute) and Radoslav Enchev (The Francis Crick Institute) on behalf of the AstraZeneca-Crick-Imperial Prosperity Partnership.

Many human diseases are caused by a deregulation of cellular components. Most traditional drugs target disease-causing proteins aiming to inhibit their activity by binding to their active site. However, specificity is often challenging, and only a small subset of these harmful proteins can be targeted in this way. A promising new class of drugs, known as induced proximity therapeutics, addresses these shortcomings by bringing two proteins close together to trigger functional changes or degradation, thereby suppressing the disease-causing effect. This shift from blocking to actively changing a protein of interest by engaging other cellular factors represents a groundbreaking new approach in drug development, expanding into previously undruggable targets to treat many diseases including cancer, inflammation, and neurodegeneration.

Programme

Speakers and panellists include: Prof Ray Deshaies (Amgen), Dr Miklos Bekes (Arvinas), Dr Leon Murphy (Casma Therapeutics), Prof Zoran Rankovic (Institute of Cancer Research), Prof Michael Bronstein (University of Oxford), Prof Charlotte Deane (EPSRC and the University of Oxford), Dr Cristina Mayor-Ruiz (IRB Barcelona), Prof Christina Woo (Harvard University), Prof Sagar Lonial (Winship Cancer Institute of Emory University), Prof Ivan Dikic (Goethe University Frankfurt)

Lectures will be followed by a Q&A panel discussion and a networking reception for in person attendees.

A more detailed programme will be made available soon.

Registration

Please find attached a poster for the event. Visit our webpages for further details and register via Eventbrite to order a free virtual or in person ticket for the event. 

Please send any questions to: medicine-at-crick@crick.ac.uk

Please feel free to circulate this information among any colleagues who may be interested.

We look forward to welcoming you to our Medicine at the Crick event.